Check out some of the stocks making the biggest moves in midday trading. Ultragenyx Pharmaceutical – Shares cratered more than 40% after Ultragenyx announced that its bone disease drug setrusumab fell short of expectations in two trials. “Neither study achieved its primary endpoint of reduction in annualized clinical fracture rate compared to placebo or bisphosphonates,” the company said in a statement. Newmont , Freeport-McMoRan – Shares of miners fell alongside the prices of gold and silver in midday trading Monday. Newmont dropped more than 5%, while Freeport-McMoran slid 2%. The Global X Silver Miners ETF (SIL) dropped more than 4%. Silver prices topped $80 per ounce in overnight trading and then tumbled more than 7% on Monday, while gold fell more than 4%. Energy stocks – Energy companies saw their shares rise as oil prices climbed more than 2%. Investors considered the prospect of peace talks in Ukraine alongside the possibility of supply disruption in the Middle East. Shares of Diamondback Energy and Devon Energy popped nearly 2%, and the energy sector of the S & P 500 was the top gainer in the index. DigitalBridge — The private equity firm that invests in data centers and other assets popped 10% . Japan’s SoftBank announced on Monday that it has entered an agreement to acquire DigitalBridge for $4 billion. Nvidia — The chipmaker fell nearly 2%. Shares gave some of their gains from last week after Nvidia bought AI chip startup Groq’s assets for about $20 billion in its largest deal on record, CNBC reported. The stock posted a 5.3% gain last week. Praxis Precision Medicines — Shares of the clinical-stage biopharmaceutical company gained 13% after BTIG called the stock a top pick for 2026. The firm also lifted its price target to $843 from $507, implying more than 213% upside for the stock. AXT — AXT fell almost 4% after the semiconductor component manufacturer said Monday it would issue more than 7 million shares of its common stock in a new public offering. The shares, priced at $12.25 each, are worth a combined roughly $87 million. — CNBC’s Liz Napolitano contributed reporting.